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butabarbital will decrease the extent or impact of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Result of coadministering a robust CYP3A4 inducer with fedratinib hasn't been analyzed.butabarbital will minimize the extent or influence of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolis